Endothelial nitric oxide synthase interactions with G-protein-coupled receptors.

  title={Endothelial nitric oxide synthase interactions with G-protein-coupled receptors.},
  author={Mario B. Marrero and Virginia J. Venema and Hong Ju and Hong He and Houjie Liang and Ruth B. Caldwell and R. Venema},
  journal={The Biochemical journal},
  volume={343 Pt 2},
The endothelial nitric oxide synthase (eNOS) is activated in response to stimulation of endothelial cells by a number of vasoactive substances including, bradykinin (BK), angiotensin II (Ang II), endothelin-1 (ET-1) and ATP. In the present study we have used in vitro activity assays of purified eNOS and in vitro binding assays with glutathione S-transferase fusion proteins to show that the capacity to bind and inhibit eNOS is a common feature of membrane-proximal regions of intracellular domain… CONTINUE READING


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