Endothelial nitric oxide synthase in bicuspid aortic valve disease.

  title={Endothelial nitric oxide synthase in bicuspid aortic valve disease.},
  author={Diana Aicher and Carmen Urbich and Andreas Michael Zeiher and Stefanie Dimmeler and Hans-Joachim Sch{\"a}fers},
  journal={The Annals of thoracic surgery},
  volume={83 4},
BACKGROUND The pathogenesis of ascending aortic dilatation in the presence of a bicuspid valve is discussed controversially. Recent experimental evidence suggests that the expression of endothelial nitric oxide synthase (eNOS) may have an influence on aortic valve anatomy and aneurysmal dilatation of the aorta. We investigated the relationship among eNOS expression, valve anatomy, and aortic dilatation in the human aortic wall. METHODS Aortic wall specimens from 39 patients with aortic valve… CONTINUE READING