Endothelial nitric oxide synthase haplotypes are related to blood pressure elevation, but not to resistance to antihypertensive drug therapy

  title={Endothelial nitric oxide synthase haplotypes are related to blood pressure elevation, but not to resistance to antihypertensive drug therapy},
  author={Val{\'e}ria Cristina Sandrim and Juan Carlos Yugar-Toledo and Zeruesenay Desta and David A. Flockhart and Heitor J{\'u}nior Moreno and Jos{\'e} Eduardo Tanus-Santos},
  journal={Journal of Hypertension},
Objectives Most hypertensive patients require two or more drugs to control arterial blood pressure effectively. Although endothelial nitric oxide synthase (eNOS) haplotypes have been associated with hypertension, it is unknown whether eNOS genotypes/haplotypes are associated with resistance to antihypertensive therapy. Methods We studied the distribution of three eNOS genetic polymorphisms: single nucleotide polymorphisms in the promoter region (T−786C), and in exon 7 (Glu298Asp), and a… 

Endothelial nitric oxide synthase haplotypes associated with hypertension do not predispose to cardiac hypertrophy.

It is suggested that eNOS haplotypes that have been associated with variable susceptibility to hypertension were not associated with LVH in hypertensive patients, even after adjustment in multiple linear regression analysis.

eNOS haplotypes affect the responsiveness to antihypertensive therapy in preeclampsia but not in gestational hypertension

Variations of the endothelial nitric oxide synthase (eNOS) gene have been associated with hypertensive disorders of pregnancy and the ‘C-Glu-a' and ‘T-Asp-a’ hapotypes were associated with responsiveness and nonresponsiveness to therapy, thus suggesting that eNOS haplotypes affect the responsiveness to antihypertensive therapy in PE.

An NOS3 Haplotype is Protective against Hypertension in a Caucasian Population

Results indicate that although individual NOS3 polymorphisms are not associated with hypertension, a rare haplotype of the gene might be protective against the development of hypertension.

eNOS haplotypes associated with gestational hypertension or preeclampsia.

A contribution of eNOS haplotypes to the development of hypertensive disorders of pregnancy that is obscured when specific eNos genotypes alone are considered is suggested.

Endothelial nitric oxide synthase polymorphisms and haplotypes in genetic epidemiology and pharmacogenetics: remarks regarding a lack of association on the risk of myocardial infarction

  • M. Luizon
  • Biology
    Molecular Biology Reports
  • 2013
The genotype and allele frequencies of 894G[T and -786T[C NOS3 polymorphisms for the healthy controls reported by the authors are compared with those reported for the populations of the HapMap Project with striking differences.



Association analyses between genetic polymorphisms of endothelial nitric oxide synthase gene and hypertension in Japanese: The Suita Study

The data suggested that polymorphisms of the eNOS gene are unlikely to be major factors in the susceptibility to hypertension in the Japanese population studied.

Endothelial nitric oxide synthase gene is positively associated with essential hypertension.

A missense variant, Glu298Asp, in exon 7 of the eNOS gene is identified and demonstrated that it is associated with both coronary spastic angina and myocardial infarction, which suggests thatIt is a genetic susceptibility factor for essential hypertension.

Influence of the endothelial nitric oxide synthase gene on conventional and ambulatory blood pressure: sib-pair analysis and haplotype study

The results pave the way for studies looking for the influence of NOS3 on blood pressure in high-risk subsets such as diabetic or hypertensive patients, and indicate the importance of ambulatory blood pressure and haplotype analysis in revealing the moderate effect of polymorphisms onBlood pressure.

Endothelial nitric oxide synthase gene haplotypes associated with circulating concentrations of nitric oxide products in healthy men

While eNOS genotypes are not significantly associated with changes in the circulating NOx concentrations, the specific eN OS haplotype that includes the ‘C’, ‘4b’ and ‘Glu’ alleles is associated with lower circulating NOX concentrations.

Association of the Glu298Asp polymorphism in the endothelial nitric oxide synthase gene with essential hypertension resistant to conventional therapy.

The Glu298Asp polymorphism may contribute to the complex pathogenesis of essential hypertension and may be a factor in the resistance of these patients to conventional antihypertensive therapy.

Effects of ethnicity on the distribution of clinically relevant endothelial nitric oxide variants.

The marked interethnic differences that are found in the distribution of eNOS variants, in the estimated haplotype frequency, and in the association between variants may help to understand how the combination of these genetic variants may influence cardiovascular diseases.