Endothelial nitric oxide synthase haplotypes are related to blood pressure elevation, but not to resistance to antihypertensive drug therapy

@article{Sandrim2006EndothelialNO,
  title={Endothelial nitric oxide synthase haplotypes are related to blood pressure elevation, but not to resistance to antihypertensive drug therapy},
  author={Val{\'e}ria Cristina Sandrim and Juan Carlos Yugar-Toledo and Zeruesenay Desta and David A. Flockhart and Heitor J{\'u}nior Moreno and Jos{\'e} Eduardo Tanus-Santos},
  journal={Journal of Hypertension},
  year={2006},
  volume={24},
  pages={2393–2397}
}
Objectives Most hypertensive patients require two or more drugs to control arterial blood pressure effectively. Although endothelial nitric oxide synthase (eNOS) haplotypes have been associated with hypertension, it is unknown whether eNOS genotypes/haplotypes are associated with resistance to antihypertensive therapy. Methods We studied the distribution of three eNOS genetic polymorphisms: single nucleotide polymorphisms in the promoter region (T−786C), and in exon 7 (Glu298Asp), and a… 

Endothelial nitric oxide synthase haplotypes associated with hypertension do not predispose to cardiac hypertrophy.

TLDR
It is suggested that eNOS haplotypes that have been associated with variable susceptibility to hypertension were not associated with LVH in hypertensive patients, even after adjustment in multiple linear regression analysis.

eNOS haplotypes affect the responsiveness to antihypertensive therapy in preeclampsia but not in gestational hypertension

TLDR
Variations of the endothelial nitric oxide synthase (eNOS) gene have been associated with hypertensive disorders of pregnancy and the ‘C-Glu-a' and ‘T-Asp-a’ hapotypes were associated with responsiveness and nonresponsiveness to therapy, thus suggesting that eNOS haplotypes affect the responsiveness to antihypertensive therapy in PE.

Endothelial nitric oxide genotypes and haplotypes are not associated with end-stage renal disease.

TLDR
The lack of significant associations between eNOS polymorphisms and ESRD suggests that eNos polymorphisms may not be relevant to the genetic component of CKD that leads to E SRD.

An NOS3 Haplotype is Protective against Hypertension in a Caucasian Population

TLDR
Results indicate that although individual NOS3 polymorphisms are not associated with hypertension, a rare haplotype of the gene might be protective against the development of hypertension.

eNOS haplotypes associated with gestational hypertension or preeclampsia.

TLDR
A contribution of eNOS haplotypes to the development of hypertensive disorders of pregnancy that is obscured when specific eNos genotypes alone are considered is suggested.
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TLDR
The data suggested that polymorphisms of the eNOS gene are unlikely to be major factors in the susceptibility to hypertension in the Japanese population studied.

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TLDR
A missense variant, Glu298Asp, in exon 7 of the eNOS gene is identified and demonstrated that it is associated with both coronary spastic angina and myocardial infarction, which suggests thatIt is a genetic susceptibility factor for essential hypertension.

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TLDR
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TLDR
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TLDR
The Glu298Asp polymorphism may contribute to the complex pathogenesis of essential hypertension and may be a factor in the resistance of these patients to conventional antihypertensive therapy.

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TLDR
The marked interethnic differences that are found in the distribution of eNOS variants, in the estimated haplotype frequency, and in the association between variants may help to understand how the combination of these genetic variants may influence cardiovascular diseases.