Endothelial nitric oxide synthase genotype modulates the improvement of coronary blood flow by pravastatin: a placebo-controlled PET study

@article{Kunnas2002EndothelialNO,
  title={Endothelial nitric oxide synthase genotype modulates the improvement of coronary blood flow by pravastatin: a placebo-controlled PET study},
  author={Tarja A. Kunnas and Terho Lehtim{\"a}ki and Reijo Laaksonen and Erkki Ilveskoski and Tuula Janatuinen and Risto Vesalainen and P. Nuutila and Pekka J. Karhunen and Juhani Knuuti and Seppo T Nikkari},
  journal={Journal of Molecular Medicine},
  year={2002},
  volume={80},
  pages={802-807}
}
The objective was to study whether coronary blood flow or its response to pravastatin are affected by genetic variation in the endothelial nitric oxide synthase (eNOS) gene. Vascular endothelial nitric oxide maintains endothelium-dependent vasodilatation and also mediates antithrombotic actions. Its formation is catalyzed by eNOS, a constitutive enzyme, which has a polymorphic site in intron 4 (4a/b). Some clinical studies have suggested an association of the rare a-allele of eNOS with… CONTINUE READING
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Endothelial nitric oxide synthase gene sequence variations and vascular disease

  • XL Wang, J Wang
  • Mol Genet Metab
  • 2000
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