Endothelial nitric oxide synthase gene intron4 VNTR polymorphism in patients with chronic kidney disease.

@article{Elshamaa2011EndothelialNO,
  title={Endothelial nitric oxide synthase gene intron4 VNTR polymorphism in patients with chronic kidney disease.},
  author={Manal F. Elshamaa and Samar Sabry and A. Hamdy Badr and Mostafa El-Ahmady and Eman A. Elghoroury and Eman Thabet and Dina Kandil and Solaf Ahmed Kamel},
  journal={Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis},
  year={2011},
  volume={22 6},
  pages={487-92}
}
Nitric oxide production is reduced in renal disease, partially due to decreased endothelial nitric oxide production. Evidence indicates that nitric oxide deficiency contributes to cardiovascular events and progression of kidney damage. A polymorphism in intron 4 of the endothelial constitutive nitric oxide synthase (ecNOS) gene is a candidate gene in… CONTINUE READING