Endothelial modulation of contractions caused by oxyhemoglobin and NG-nitro-L-arginine in isolated dog and monkey cerebral arteries.

@article{Toda1993EndothelialMO,
  title={Endothelial modulation of contractions caused by oxyhemoglobin and NG-nitro-L-arginine in isolated dog and monkey cerebral arteries.},
  author={Noboru Toda and Kazuhide Ayajiki and Tomio Okamura},
  journal={Stroke},
  year={1993},
  volume={24 10},
  pages={1584-8; discussion 1589}
}
BACKGROUND AND PURPOSE Oxyhemoglobin is a key substance in provoking cerebral vasospasm and a scavenger of nitric oxide. The present study was designed to determine whether suppression of the action of endothelium-derived nitric oxide is involved in oxyhemoglobin-induced cerebroarterial contraction. METHODS Dog and monkey cerebral artery strips with and without endothelium were immersed for isometric tension recording in modified Ringer-Locke solution aerated with 95% oxygen and 5% carbon… CONTINUE READING