Endothelial microparticles in mild chronic obstructive pulmonary disease and emphysema. The Multi-Ethnic Study of Atherosclerosis Chronic Obstructive Pulmonary Disease study.

@article{Thomashow2013EndothelialMI,
  title={Endothelial microparticles in mild chronic obstructive pulmonary disease and emphysema. The Multi-Ethnic Study of Atherosclerosis Chronic Obstructive Pulmonary Disease study.},
  author={Michael A Thomashow and Daichi Shimbo and Megha A. Parikh and Eric A. Hoffman and Jens Vogel-Claussen and Katja Hueper and Jessie Fanglu Fu and Chia-Ying Liu and David A. Bluemke and Corey E Ventetuolo and Margaret F Doyle and Robert G. Barr},
  journal={American journal of respiratory and critical care medicine},
  year={2013},
  volume={188 1},
  pages={60-8}
}
RATIONALE Basic research implicates alveolar endothelial cell apoptosis in the pathogenesis of chronic obstructive pulmonary disease (COPD) and emphysema. However, information on endothelial microparticles (EMPs) in mild COPD and emphysema is lacking. OBJECTIVES We hypothesized that levels of CD31(+) EMPs phenotypic for endothelial cell apoptosis would be elevated in COPD and associated with percent emphysema on computed tomography (CT). Associations with pulmonary microvascular blood flow… CONTINUE READING

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