Endothelial lipase promotes the catabolism of ApoB-containing lipoproteins.

  title={Endothelial lipase promotes the catabolism of ApoB-containing lipoproteins.},
  author={Uli C. Broedl and Cyrille Maugeais and John S Millar and Weijun Jin and Ryan E Moore and Ilia V. Fuki and Dawn H L Marchadier and Jane M. Glick and Daniel J. Rader},
  journal={Circulation research},
  volume={94 12},
Endothelial lipase (EL) has been found to be a key enzyme in high-density lipoprotein (HDL) metabolism in mice, leading to the concept that inhibition of EL could be a novel strategy for raising HDL cholesterol levels. However, mice are "HDL animals" and the effect of EL on atherogenic apoB-containing lipoproteins has not been elucidated. We previously found that EL is capable of hydrolyzing very low-density lipoprotein (VLDL) and LDL lipids ex vivo. To investigate the role of EL in the… CONTINUE READING
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