Endothelial lipase is synthesized by hepatic and aorta endothelial cells and its expression is altered in apoE-deficient mice.

@article{Yu2004EndothelialLI,
  title={Endothelial lipase is synthesized by hepatic and aorta endothelial cells and its expression is altered in apoE-deficient mice.},
  author={Kenneth C-W Yu and Christopher Aw David and Sujata Kadambi and Andreas Stahl and Ken-ichi Hirata and Tatsuro Ishida and Thomas Quertermous and Allen D. Cooper and Sungshin Y Choi},
  journal={Journal of lipid research},
  year={2004},
  volume={45 9},
  pages={1614-23}
}
Both LPL and HL are synthesized in parenchymal cells, are secreted, and bind to endothelial cells. To learn where endothelial lipase (EL) is synthesized in adult animals, the localization of EL in mouse and rat liver was studied by immunohistochemical analysis. Furthermore, to test whether EL could play a role in atherogenesis, the expression of EL in the aorta and liver of apolipoprotein E knockout (EKO) mice was determined. EL in both mouse and rat liver was colocalized with vascular… CONTINUE READING

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