Endothelial lipase is a major determinant of HDL level.

@article{Ishida2003EndothelialLI,
  title={Endothelial lipase is a major determinant of HDL level.},
  author={Tatsuro Ishida and Sungshin Y Choi and Ramendra K. Kundu and Ken-Ichi Hirata and Edward M. Rubin and Allen D. Cooper and Thomas Quertermous},
  journal={The Journal of clinical investigation},
  year={2003},
  volume={111 3},
  pages={347-55}
}
A new member of the lipase gene family, initially termed endothelial lipase (gene nomenclature, LIPG; protein, EL), is expressed in a variety of different tissues, suggesting a general role in lipid metabolism. To assess the hypothesis that EL plays a physiological role in lipoprotein metabolism in vivo, we have used gene targeting of the native murine locus and transgenic introduction of the human LIPG locus in mice to modulate the level of EL expression. Evaluation of these alleles in a C57Bl… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 112 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 26 references

A novel endothelial-derived lipase that modulates HDL metabolism

Nature Genetics • 1999
View 17 Excerpts
Highly Influenced

Cloning of a unique lipase from endothelial cells extends the lipase gene family

K Hirata
J. Biol • 1999
View 5 Excerpts
Highly Influenced

A rapid method of total lipid extraction and purification.

Canadian journal of biochemistry and physiology • 1959
View 3 Excerpts
Highly Influenced

Characterization of the lipolytic activity of endothelial lipase

McCoy, M.G
J. Lipid Res • 2002
View 2 Excerpts

Lipoprotein lipase: physiology, biochemistry, and molecular biology.

Frontiers in bioscience : a journal and virtual library • 2001

Similar Papers

Loading similar papers…