Endothelial lipase is a major determinant of HDL level.

  title={Endothelial lipase is a major determinant of HDL level.},
  author={Tatsuro Ishida and Sungshin Y Choi and Ramendra K. Kundu and Ken-Ichi Hirata and Edward M. Rubin and Allen D. Cooper and Thomas Quertermous},
  journal={The Journal of clinical investigation},
  volume={111 3},
A new member of the lipase gene family, initially termed endothelial lipase (gene nomenclature, LIPG; protein, EL), is expressed in a variety of different tissues, suggesting a general role in lipid metabolism. To assess the hypothesis that EL plays a physiological role in lipoprotein metabolism in vivo, we have used gene targeting of the native murine locus and transgenic introduction of the human LIPG locus in mice to modulate the level of EL expression. Evaluation of these alleles in a C57Bl… CONTINUE READING

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