Endothelial jagged-2 sustains hematopoietic stem and progenitor reconstitution after myelosuppression

@inproceedings{Guo2017EndothelialJS,
  title={Endothelial jagged-2 sustains hematopoietic stem and progenitor reconstitution after myelosuppression},
  author={Peipei Guo and Michael G. Poulos and Brisa Palikuqi and Chaitanya R. Badwe and Raphael Lis and Balvir Kunar and Bi-Sen Ding and Sina Y. Rabbany and Koji Shido and Jason M. Butler and Shahin Rafii},
  booktitle={The Journal of clinical investigation},
  year={2017}
}
Angiocrine factors, such as Notch ligands, supplied by the specialized endothelial cells (ECs) within the bone marrow and splenic vascular niche play an essential role in modulating the physiology of adult hematopoietic stem and progenitor cells (HSPCs). However, the relative contribution of various Notch ligands, specifically jagged-2, to the homeostasis of HSPCs is unknown. Here, we show that under steady state, jagged-2 is differentially expressed in tissue-specific vascular beds, but its… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 5 times over the past 90 days. VIEW TWEETS
2 Citations
29 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 29 references

Similar Papers

Loading similar papers…