Endothelial glutathione-S-transferase A4-4 protects against oxidative stress and modulates iNOS expression through NF-kappaB translocation.

@article{Yang2008EndothelialGA,
  title={Endothelial glutathione-S-transferase A4-4 protects against oxidative stress and modulates iNOS expression through NF-kappaB translocation.},
  author={Yongzhen Yang and Yusong Yang and Ya Fei Xu and Scott D. Lick and Yogesh C. Awasthi and Paul J. Boor},
  journal={Toxicology and applied pharmacology},
  year={2008},
  volume={230 2},
  pages={187-96}
}
Our recent work in endothelial cells and human atherosclerotic plaque showed that overexpression of glutathione-S-tranferases (GSTs) in endothelium protects against oxidative damage from aldehydes such as 4-HNE. Nuclear factor (NF)-kappaB plays a crucial role during inflammation and immune responses by regulating the expression of inducible genes such as inducible nitric oxide synthase (iNOS). 4-HNE induces apoptosis and affects NF-kappaB mediated gene expression, but conflicting results on 4… CONTINUE READING

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