Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice.

@article{Csiszr2008EndothelialFA,
  title={Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice.},
  author={Anna Csisz{\'a}r and Nazar Labinskyy and Viviana M P{\'e}rez and Fabio A. Recchia and Andrej Podlutsky and Partha Mukhopadhyay and Gy{\"o}rgy Losonczy and P{\'a}l Pacher and S N Austad and Andrzej Bartke and Zoltan Ungvari},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2008},
  volume={295 5},
  pages={
          H1882-94
        }
}
Hypopituitary Ames dwarf mice have low circulating growth hormone (GH)/IGF-I levels, and they have extended longevity and exhibit many symptoms of delayed aging. To elucidate the vascular consequences of Ames dwarfism we compared endothelial O2(-) and H2O2 production, mitochondrial reactive oxygen species (ROS) generation, expression of antioxidant enzymes, and nitric oxide (NO) production in aortas of Ames dwarf and wild-type control mice. In Ames dwarf aortas endothelial O2(-) and H2O2… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 66 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 60 references

Vascular O2.- and H2O2 production and oxidative stress resistance in two closely related rodent species with disparate longevity

  • A Csiszar, N Labinskyy, +10 authors Z. Ungvari
  • Aging Cell: (in press),
  • 2007
Highly Influential
8 Excerpts

Similar Papers

Loading similar papers…