Endothelial fluid shear stress sensing in vascular health and disease.

  title={Endothelial fluid shear stress sensing in vascular health and disease.},
  author={Nicolas Baeyens and Chirosree Bandyopadhyay and Brian G Coon and Sanguk Yun and Martin A Schwartz},
  journal={The Journal of clinical investigation},
  volume={126 3},
Endothelial cells transduce the frictional force from blood flow (fluid shear stress) into biochemical signals that regulate gene expression and cell behavior via specialized mechanisms and pathways. These pathways shape the vascular system during development and during postnatal and adult life to optimize flow to tissues. The same pathways also contribute to atherosclerosis and vascular malformations. This Review covers recent advances in basic mechanisms of flow signaling and the involvement… CONTINUE READING
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