Endothelial expression of the 5-hydroxytryptamine1B antimigraine drug receptor in rat and human brain microvessels.

@article{Riad1998EndothelialEO,
  title={Endothelial expression of the 5-hydroxytryptamine1B antimigraine drug receptor in rat and human brain microvessels.},
  author={Mustapha Riad and Xin-Kang Tong and Salah El Mestikawy and Michel Hamon and Edith Hamel and Laurent Descarries},
  journal={Neuroscience},
  year={1998},
  volume={86 4},
  pages={1031-5}
}
In addition to triggering vasoconstriction of peripheral blood vessels, which led to its discovery as a circulating neurohormone 50 years ago, serotonin (5-hydroxytryptamine) acts as a neurotransmitter/ modulator in the central nervous system and regulates local cerebral blood flow and vascular permeability through direct and indirect effects on intraparenchymal microvessels. Among the various 5-hydroxytryptamine receptors which mediate these effects, particular attention has been paid to the 5… CONTINUE READING
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