Endothelial enriched microRNAs regulate angiotensin II-induced endothelial inflammation and migration.

@article{Zhu2011EndothelialEM,
  title={Endothelial enriched microRNAs regulate angiotensin II-induced endothelial inflammation and migration.},
  author={Ni Zhu and Dongze Zhang and Sifeng Chen and Xuemei Liu and Li Lin and Xinmiao Huang and Zhifu Guo and Juan Liu and Yanrong Wang and Wenjun Yuan and Yongwen Qin},
  journal={Atherosclerosis},
  year={2011},
  volume={215 2},
  pages={
          286-93
        }
}
Inflammation is observed at all stages of atherosclerosis. The initial stage of atherosclerosis is characterized by recruitment of leukocytes to activated endothelial cells (ECs). MicroRNAs (miRNAs) are a class of 19-25 nucleotides, non-protein-coding RNAs that repress target gene expression by translational inhibition or mRNA degradation. The link between miRNA and endothelial functions is largely unknown. Northern blot showed that miR-155 and miR-221 were highly expressed in human umbilical… CONTINUE READING
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