Endothelial dysfunction precedes development of microalbuminuria in IDDM.

Abstract

In patients with insulin-dependent diabetes mellitus (IDDM), microalbuminuria is a predictor of widespread severe microangiopathy and macroangiopathy. Patients with microalbuminuria show generalized dysfunction of the vascular endothelium, but it is unknown whether endothelial dysfunction precedes the development of microalbuminuria. We examined a cohort of… (More)

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@article{Stehouwer1995EndothelialDP, title={Endothelial dysfunction precedes development of microalbuminuria in IDDM.}, author={C D A Coen Stehouwer and H. R. Fischer and Arno W. R. van Kuijk and Ben Polak and Ab. J. M. Donker}, journal={Diabetes}, year={1995}, volume={44 5}, pages={561-4} }