Endothelial dysfunction of the coronary microvasculature is associated with coronary blood flow regulation in patients with early atherosclerosis.

@article{Zeiher1991EndothelialDO,
  title={Endothelial dysfunction of the coronary microvasculature is associated with coronary blood flow regulation in patients with early atherosclerosis.},
  author={Andreas Michael Zeiher and Heinz Drexler and Helmut Wollschl{\"a}ger and Herwig Just},
  journal={Circulation},
  year={1991},
  volume={84 5},
  pages={1984-92}
}
BACKGROUND The vascular endothelium is capable of regulating tissue perfusion by the release of endothelium-derived relaxing factor to modulate vasomotor tone of the resistance vasculature. METHODS AND RESULTS To test whether atherosclerosis is associated with a functional abnormality of endothelium-mediated microvascular relaxation affecting coronary blood flow regulation, we compared coronary blood flow responses with cold pressor testing with the response of the coronary vasculature to… CONTINUE READING

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