Endothelial dysfunction in the pulmonary artery induced by concentrated fine particulate matter exposure is associated with local but not systemic inflammation.

@article{Davel2012EndothelialDI,
  title={Endothelial dysfunction in the pulmonary artery induced by concentrated fine particulate matter exposure is associated with local but not systemic inflammation.},
  author={Ana Paula Couto Davel and Miriam Lemos and Luciana Duzolina Manfr{\'e} Pastro and Sibelli Silva Cosme Pedro and Paulo Afonso de Andr{\'e} and Cristina Bichels Hebeda and Sandra H P Farsky and Paulo Hil{\'a}rio Nascimento Saldiva and Luciana V Rossoni},
  journal={Toxicology},
  year={2012},
  volume={295 1-3},
  pages={39-46}
}
Clinical evidence has identified the pulmonary circulation as an important target of air pollution. It was previously demonstrated that in vitro exposure to fine particulate matter (aerodynamic diameter≤2.5 μm, PM2.5) induces endothelial dysfunction in isolated pulmonary arteries. We aimed to investigate the effects of in vivo exposure to urban concentrated PM2.5 on rat pulmonary artery reactivity and the mechanisms involved. For this, adult Wistar rats were exposed to 2 weeks of concentrated S… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

In Vitro and In Vivo Experimental Studies of PM2.5 on Disease Progression

International journal of environmental research and public health • 2018

Similar Papers

Loading similar papers…