Endothelial dysfunction in hypercholesterolemia is corrected by L-arginine.

Abstract

Hypercholesterolemia attenuates endothelium-dependent vasorelaxation and augments the responses to vasoconstrictor agents. Both effects are largely due to a reduction in the release of endothelium-derived relaxing factor. Since endothelium-derived relaxing factor is now known to be nitric oxide derived from the metabolism of L-arginine, we hypothesized that… (More)

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Cite this paper

@article{Cooke1991EndothelialDI, title={Endothelial dysfunction in hypercholesterolemia is corrected by L-arginine.}, author={Jonathon Cooke and Jacqueline R Dzau and Andrew J. Creager}, journal={Basic research in cardiology}, year={1991}, volume={86 Suppl 2}, pages={173-81} }