Endothelial dysfunction in aged humans is related with oxidative stress and vascular inflammation

@article{RodrguezMaas2009EndothelialDI,
  title={Endothelial dysfunction in aged humans is related with oxidative stress and vascular inflammation},
  author={Leocadio Rodr{\'i}guez-Ma{\~n}as and Mariam El-Assar and Susana Vallejo and Pedro L{\'o}pez-D{\'o}riga and Joaqu{\'i}n Sol{\'i}s and Roberto Petidier and Manuel Villanueva Montes and Juli{\'a}n Nevado and Marta Castro and Carmen G{\'o}mez-Guerrero and Concepci{\'o}n Peir{\'o} and Carlos F. S{\'a}nchez‐Ferrer},
  journal={Aging Cell},
  year={2009},
  volume={8}
}
Vascular endothelial dysfunction occurs during the human aging process, and it is considered as a crucial event in the development of many vasculopathies. We investigated the underlying mechanisms of this process, particularly those related with oxidative stress and inflammation, in the vasculature of subjects aged 18–91 years without cardiovascular disease or risk factors. In isolated mesenteric microvessels from these subjects, an age‐dependent impairment of the endothelium‐dependent… 
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