Endothelial dysfunction enhances vasoconstriction due to scavenging of nitric oxide by a hemoglobin-based oxygen carrier.

@article{Yu2010EndothelialDE,
  title={Endothelial dysfunction enhances vasoconstriction due to scavenging of nitric oxide by a hemoglobin-based oxygen carrier.},
  author={Binglan Yu and Mohd Shahid and Elena M. Egorina and Mikhail A. Sovershaev and Michael J. Raher and Chong Lei and Mei X. Wu and Kenneth D. Bloch and Warren M. Zapol},
  journal={Anesthesiology},
  year={2010},
  volume={112 3},
  pages={586-94}
}
BACKGROUND To date, there is no safe and effective hemoglobin-based oxygen carrier (HBOC) to substitute for erythrocyte transfusion. It is uncertain whether a deficiency of endothelial nitric oxide bioavailability (endothelial dysfunction) prevents or augments HBOC-induced vasoconstriction. METHODS Hemodynamic effects of infusion of PolyHeme (1.08 g hemoglobin/kg; Northfield Laboratories, Evanston, IL) or murine tetrameric hemoglobin (0.48 g hemoglobin/kg) were determined in awake healthy… CONTINUE READING

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