Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus.

  title={Endothelial dysfunction and hypertension in rats transduced with CYP4A2 adenovirus.},
  author={Ji-shi Wang and Harpreet Singh and Frank Zhang and Tsuneo Ishizuka and Huan Deng and Rowena Kemp and Michael S. Wolin and Thomas H. Hintze and Nader G Abraham and Alberto Nasjletti and Michal Laniado-Schwartzman},
  journal={Circulation research},
  volume={98 7},
Vascular cytochrome P450 (CYP) 4A enzymes catalyze the synthesis of 20-hydroxyeicosatetraenoic acid (20-HETE), an eicosanoid which participates in the regulation of vascular tone by sensitizing the smooth muscle cells to constrictor and myogenic stimuli. This study was undertaken to investigate the consequences of CYP4A overexpression on blood pressure and endothelial function in rats treated with adenoviral vectors carrying the CYP4A2 construct. Intravenous injection of Adv-CYP4A2 increased… CONTINUE READING


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