Endothelial dysfunction, impaired endogenous fibrinolysis, and cigarette smoking: a mechanism for arterial thrombosis and myocardial infarction.

@article{Newby1999EndothelialDI,
  title={Endothelial dysfunction, impaired endogenous fibrinolysis, and cigarette smoking: a mechanism for arterial thrombosis and myocardial infarction.},
  author={David E. Newby and Robert A. Wright and C Labinjoh and Christopher A. Ludlam and Keith A. A. Fox and Nicholas A. Boon and David J. Webb},
  journal={Circulation},
  year={1999},
  volume={99 11},
  pages={1411-5}
}
BACKGROUND Effective endogenous fibrinolysis requires rapid release of tissue plasminogen activator (tPA) from the vascular endothelium. Smoking is a known risk factor for arterial thrombosis and myocardial infarction, and it causes endothelial dysfunction. We therefore examined the effects of cigarette smoking on substance P-induced tPA release in vivo in humans. METHODS AND RESULTS Blood flow and plasma fibrinolytic factors were measured in both forearms of 12 smokers and 12 age- and sex… CONTINUE READING