Endothelial dysfunction, hemodynamic forces, and atherogenesis.

  title={Endothelial dysfunction, hemodynamic forces, and atherogenesis.},
  author={Michael A. Gimbrone and James N. Topper and Tobi Nagel and Keith R. Anderson and Guillermo Garc{\'i}a-Carde{\~n}a},
  journal={Annals of the New York Academy of Sciences},
  pages={230-9; discussion 239-40}
Phenotypic modulation of endothelium to a dysfunctional state contributes to the pathogenesis of cardiovascular diseases such as atherosclerosis. The localization of atherosclerotic lesions to arterial geometries associated with disturbed flow patterns suggests an important role for local hemodynamic forces in atherogenesis. There is increasing evidence that the vascular endothelium, which is directly exposed to various fluid mechanical forces generated by pulsatile blood flow, can discriminate… CONTINUE READING
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Flow - mediated endothelial mechanotransduction

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  • Physiol . Rev .
  • 1995

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