Endothelial differentiation of adipose-derived mesenchymal stem cells is improved by epigenetic modifying drug BIX-01294.

@article{Culmes2013EndothelialDO,
  title={Endothelial differentiation of adipose-derived mesenchymal stem cells is improved by epigenetic modifying drug BIX-01294.},
  author={Mihaela Culmes and Hans-Henning Eckstein and Rainer Burgkart and Andreas K. N{\"u}ssler and Michael G{\"u}nther and Ernst Wagner and Jaroslav Pelisek},
  journal={European journal of cell biology},
  year={2013},
  volume={92 2},
  pages={
          70-9
        }
}
Chromatin remodeling plays an essential role in regulation of gene transcription. Consequently, targeted changes in chromatin may also augment pluripotency of somatic cells. The aim of the present study was to evaluate the effect of epigenetic drug BIX-01294 (BIX), a histone G9a inhibitor, on DNA methylation, expression of pluripotency genes POU5F1 (isoform a), NANOG, KLF4, and CMYC in mesenchymal stem cells, and the ability to increase their differentiation potential into endothelial cells… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 19 CITATIONS

Epigenetic changes in mesenchymal stem cells differentiation.

  • European journal of medical genetics
  • 2017
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 40 REFERENCES

Randomised comparison of G - CSF - mobilized peripheral blood mononuclear cells versus bone marrow - mononuclear cells for the treatment of patients with lower limb arteriosclerosis obliterans

A. F. Karamysheva
  • Thromb . Haemost .
  • 2008
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL