Endothelial-derived superoxide anions in pig coronary arteries: evidence from lucigenin chemiluminescence and histochemical techniques.

@article{Brandes1997EndothelialderivedSA,
  title={Endothelial-derived superoxide anions in pig coronary arteries: evidence from lucigenin chemiluminescence and histochemical techniques.},
  author={Ralf Peter Brandes and Matthias Barton and K M Philippens and Gerd Schweitzer and Andreas Muegge},
  journal={The Journal of physiology},
  year={1997},
  volume={500 ( Pt 2)},
  pages={331-42}
}
1. The generation of superoxide anions (O2-) by intact pig coronary artery rings was measured using a lucigenin-enhanced chemiluminescence technique and a histochemical technique with Nitroblue Tetrazolium (NBT) staining. 2. Isolated arteries with intact endothelium generated O2- at a rate of 9.0 +/- 0.8 pmol min-1 (mg dry weight)-1; this rate was diminished by about 24% when the endothelium was removed. The NBT staining of arterial ring preparations showed formazan precipitation mainly in the… CONTINUE READING

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