Endothelial-derived nitric oxide inhibits sodium transport by affecting apical membrane channels in cultured collecting duct cells.

@article{Stoos1994EndothelialderivedNO,
  title={Endothelial-derived nitric oxide inhibits sodium transport by affecting apical membrane channels in cultured collecting duct cells.},
  author={Barbara A Stoos and Oscar A. Carretero and Jeffrey L. Garvin},
  journal={Journal of the American Society of Nephrology : JASN},
  year={1994},
  volume={4 11},
  pages={1855-60}
}
Previously, it has been shown that the addition of bradykinin (Bk) to M-1 cortical collecting duct cells in the presence of endothelial cells decreased short-circuit current (Isc), a measure of net active transport. This effect is presumably due to the release of endothelium-derived nitric oxide (EDNO), because the decrease in Isc could be blocked with Nw-nitro-L-arginine. To show that the inhibition of Isc was due to EDNO rather than prostaglandins, the ability of a cyclooxygenase inhibitor to… CONTINUE READING
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