Endothelial control of lower limb blood flow in chronic heart failure.

  title={Endothelial control of lower limb blood flow in chronic heart failure.},
  author={David C Lindsay and Diana R. Holdright and Debbie Clarke and Inder S. Anand and P Poole-wilson and Peter Collins},
  volume={75 5},
BACKGROUND Limitation of the blood supply to skeletal muscle in chronic heart failure may contribute to the symptoms of fatigue and diminished exercise capacity. The pathophysiology underlying this abnormality is not known. The purpose of this study was to assess the effect of endothelium dependent and independent vasodilator agents on blood flow in the leg of patients with heart failure. METHODS AND RESULTS Blood flow in the leg was measured in patients with heart failure (n = 20) and… CONTINUE READING


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