Endothelial control of arterial distensibility is impaired in chronic heart failure.

@article{Ramsey1995EndothelialCO,
  title={Endothelial control of arterial distensibility is impaired in chronic heart failure.},
  author={Mike W. Ramsey and Jonathan Goodfellow and Christopher J. H. Jones and Lisa Luddington and Malcolm J. Lewis and Andrew H. Henderson},
  journal={Circulation},
  year={1995},
  volume={92 11},
  pages={3212-9}
}
BACKGROUND Vascular tone is a determinant of conduit artery distensibility. The aim of this study was to establish whether endothelium-derived relaxing factor (EDRF) influences the distensibility of conduit arteries and whether endothelium-mediated increases in distensibility are impaired in chronic heart failure (CHF). METHODS AND RESULTS Conduit artery distensibility was measured by two methods in healthy subjects and in nine patients with CHF caused by dilated cardiomyopathy. In the first… CONTINUE READING