Endothelial connexin 37, connexin 40, and connexin 43 respond uniquely to substrate and shear stress.

@article{Johnson2007EndothelialC3,
  title={Endothelial connexin 37, connexin 40, and connexin 43 respond uniquely to substrate and shear stress.},
  author={Tiffany L Johnson and Robert M. Nerem},
  journal={Endothelium : journal of endothelial cell research},
  year={2007},
  volume={14 4-5},
  pages={215-26}
}
Endothelial connexins have been linked to atherosclerosis and hypertension; however, little is know about their sensitivity to stimuli and individual functions. This study investigates the responses of endothelial connexin 37, connexin 40, and connexin 43 (Cx37, Cx40, and Cx43) to shear stress and substrate. Human endothelial cells were seeded on adsorbed collagen or a collagen gel containing smooth muscle cells and exposed to static or laminar shear stress. Connexin mRNA, protein, and gap… CONTINUE READING
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