Endothelial cells promote neural stem cell proliferation and differentiation associated with VEGF activated Notch and Pten signaling.

@article{Sun2010EndothelialCP,
  title={Endothelial cells promote neural stem cell proliferation and differentiation associated with VEGF activated Notch and Pten signaling.},
  author={Jinqiao Sun and Wenhao Zhou and Duan Ma and Yi Yang},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  year={2010},
  volume={239 9},
  pages={2345-53}
}
To investigate whether and how endothelial cells affect neurogenesis, we established a system to co-culture endothelial cells and brain slices of neonatal rat and observed how subventricular zone cells differentiate in the presence of endothelial cells. In the presence of endothelial cells, neural stem cells increased in number, as did differentiated neurons and glia. The augmentation of neurogenesis was reversed by diminishing vascular endothelial growth factor (VEGF) expression in endothelial… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

Bipotent progenitors as embryonic origin of retinal stem cells

The Journal of cell biology • 2017
View 2 Excerpts

Similar Papers

Loading similar papers…