Endothelial cells metabolize NG-monomethyl-L-arginine to L-citrulline and subsequently to L-arginine.

@article{Hecker1990EndothelialCM,
  title={Endothelial cells metabolize NG-monomethyl-L-arginine to L-citrulline and subsequently to L-arginine.},
  author={Markus Hecker and Jane A Mitchell and Hayley J. Harris and Masashi Katsura and Christoph Thiemermann and John R. Vane},
  journal={Biochemical and biophysical research communications},
  year={1990},
  volume={167 3},
  pages={
          1037-43
        }
}
NG-monomethyl-L-arginine (MeArg) inhibits the release of endothelium-derived relaxing factor (EDRF) from endothelial cells (EC) and the formation of nitric oxide (NO) from L-arginine (Arg) in EC and activated macrophages. We have compared the inhibitory potency of MeArg to that of N omega-nitro-L-arginine (NO2Arg), a more potent inhibitor of EDRF synthesis in vitro. NO2Arg (100 microM) was significantly more potent than MeArg in inhibiting the endothelium-dependent relaxation of rabbit aorta… CONTINUE READING
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