Endothelial cells in culture produce a vasoconstrictor substance.

  title={Endothelial cells in culture produce a vasoconstrictor substance.},
  author={Rebbeca O'Brien and Raymond J. Robbins and Ivan F. McMurtry},
  journal={Journal of cellular physiology},
  volume={132 2},
We report that cultured vascular endothelial cells release into the culture medium a vasoconstrictor peptide, a substance we call an endothelium-derived constricting factor (EDCF). Conditioned medium from cultured bovine aortic and pulmonary artery endothelial cells caused sustained, dose-dependent isometric constriction of vascular rings isolated from bovine coronary and pulmonary arteries and rat and guinea pig pulmonary arteries and aortas. The medium also caused vasoconstriction when… CONTINUE READING


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