Endothelial cells from visceral adipose tissue disrupt adipocyte functions in a three-dimensional setting: partial rescue by angiopoietin-1.

@article{Pellegrinelli2014EndothelialCF,
  title={Endothelial cells from visceral adipose tissue disrupt adipocyte functions in a three-dimensional setting: partial rescue by angiopoietin-1.},
  author={Vanessa Pellegrinelli and Christine Rouault and Nicolas Veyrie and Karine Cl{\'e}ment and Dani{\`e}le Lacasa},
  journal={Diabetes},
  year={2014},
  volume={63 2},
  pages={535-49}
}
During obesity, chronic inflammation of human white adipose tissue (WAT) is associated with metabolic and vascular alterations. Endothelial cells from visceral WAT (VAT-ECs) exhibit a proinflammatory and senescent phenotype and could alter adipocyte functions. We aimed to determine the contribution of VAT-ECs to adipocyte dysfunction related to inflammation and to rescue these alterations by anti-inflammatory strategies. We developed an original three-dimensional setting allowing maintenance of… CONTINUE READING
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