Endothelial cells elicit immune-enhancing responses to dengue virus infection.

  title={Endothelial cells elicit immune-enhancing responses to dengue virus infection.},
  author={Nadine A. Dalrymple and Erich R. Mackow},
  journal={Journal of virology},
  volume={86 12},
Dengue viruses cause two severe diseases that alter vascular fluid barrier functions, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Preexisting antibodies to dengue virus disposes patients to immune-enhanced edema (DSS) or hemorrhagic (DHF) disease following infection by a discrete dengue virus serotype. Although the endothelium is the primary vascular fluid barrier, direct effects of dengue virus on endothelial cells (ECs) have not been considered primary factors in… CONTINUE READING
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