Endothelial cells are susceptible to rapid siRNA transfection and gene silencing ex vivo.

Abstract

BACKGROUND Endothelial gene silencing via small interfering RNA (siRNA) transfection represents a promising strategy for the control of vascular disease. Here, we demonstrate endothelial gene silencing in human saphenous vein using three rapid siRNA transfection techniques amenable for use in the operating room. METHODS Control siRNA, Cy5 siRNA, or siRNA… (More)
DOI: 10.1016/j.jvs.2010.06.169

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