Endothelial cell surface F1-F0 ATP synthase is active in ATP synthesis and is inhibited by angiostatin.

  title={Endothelial cell surface F1-F0 ATP synthase is active in ATP synthesis and is inhibited by angiostatin.},
  author={Tammy L Moser and D J Kenan and Timothy A Ashley and J. L. A. M. Van Roy and Michael D. Goodman and Uma Kant Misra and Dennis J. Cheek and Salvatore Vincent Pizzo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={98 12},
Angiostatin blocks tumor angiogenesis in vivo, almost certainly through its demonstrated ability to block endothelial cell migration and proliferation. Although the mechanism of angiostatin action remains unknown, identification of F(1)-F(O) ATP synthase as the major angiostatin-binding site on the endothelial cell surface suggests that ATP metabolism may play a role in the angiostatin response. Previous studies noting the presence of F(1) ATP synthase subunits on endothelial cells and certain… CONTINUE READING
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