Endothelial cell-specific activation of transforming growth factor-β signaling in mice induces cutaneous, visceral, and microvascular fibrosis.

Abstract

In this study, we tested the hypothesis that constitutive endothelial cell-specific activation of TGF-β signaling induces tissue fibrosis and vasculopathy resembling the characteristic fibrotic and vascular alterations of systemic sclerosis. Transgenic mice with inducible expression of a constitutively active TGF-β receptor I specifically in endothelial… (More)
DOI: 10.1038/labinvest.2017.23

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Cite this paper

@article{Wermuth2017EndothelialCA, title={Endothelial cell-specific activation of transforming growth factor-β signaling in mice induces cutaneous, visceral, and microvascular fibrosis.}, author={Peter J Wermuth and Kellan R Carney and Fabian Mendoza and Sonsoles Piera-Vel{\'a}zquez and Sergio Jim{\'e}nez}, journal={Laboratory investigation; a journal of technical methods and pathology}, year={2017}, volume={97 7}, pages={806-818} }