Endothelial cell signaling and cytoskeletal changes in response to shear stress.

@article{Girard1993EndothelialCS,
  title={Endothelial cell signaling and cytoskeletal changes in response to shear stress.},
  author={Peggy R. Girard and Robert M. Nerem},
  journal={Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering},
  year={1993},
  volume={5 1},
  pages={31-6}
}
Endothelial cells exposed to a fluid shear stress both in vivo and in vitro show an alignment with the direction of flow and an elongation of cells with a concomitant reorganization of their F-actin microfilament network. Specialized regions of the plasma membrane known as focal contacts are sites of transmembrane linkages between the actin microfilament bundles and the extracellular matrix (ECM) where cytoskeletal organization and, hence, cellular morphological changes may be modulated. Focal… CONTINUE READING