Endothelial cell-selective adhesion molecule regulates albuminuria in diabetic nephropathy.

@article{Hara2009EndothelialCA,
  title={Endothelial cell-selective adhesion molecule regulates albuminuria in diabetic nephropathy.},
  author={Tetsuya Hara and Tatsuro Ishida and Husni M. Cangara and Ken‐ichi Hirata},
  journal={Microvascular research},
  year={2009},
  volume={77 3},
  pages={
          348-55
        }
}
Microalbuminuria is a primary manifestation of diabetic nephropathy. Endothelial cell-selective adhesion molecule (ESAM) is a new member of the immunoglobulin superfamily which is selectively expressed by vascular endothelial cells. Although ESAM mediates homophilic interaction between endothelial cells, the role of ESAM in glomerular permeability remains unknown. We examined the expression and function of ESAM in the high glucose-induced microangiopathy in the kidney. ESAM was highly expressed… CONTINUE READING
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