Endothelial cell seeding of (heparinized) collagen matrices: effects of bFGF pre-loading on proliferation (after low density seeding) and pro-coagulant factors.

@article{Wissink2000EndothelialCS,
  title={Endothelial cell seeding of (heparinized) collagen matrices: effects of bFGF pre-loading on proliferation (after low density seeding) and pro-coagulant factors.},
  author={M J Wissink and R Beernink and Nicole M. Scharenborg and Andr{\'e} A. Poot and Gerard H M Engbers and T. Beugeling and Willem van Aken and Jan Feijen},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2000},
  volume={67 2-3},
  pages={141-55}
}
Endothelial cell seeding to improve the performance of small-diameter vascular grafts requires a suitable substrate, such as crosslinked collagen. In addition to providing a suitable substrate for adhesion and growth of endothelial cells, proliferation of seeded endothelial cells can be enhanced by local, sustained release of basic fibroblast growth factor (bFGF, a heparin-binding growth factor for endothelial cells). We have previously shown that collagen crosslinked using N-(3… CONTINUE READING