Endothelial cell modulation of bone marrow stromal cell osteogenic potential.

  title={Endothelial cell modulation of bone marrow stromal cell osteogenic potential.},
  author={Darnell Kaigler and Paul H Krebsbach and Erin R West and Kim S Horger and Yen-Chen Huang and David J Mooney},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={19 6},
In the context of bone development and regeneration, the intimate association of the vascular endothelium with osteogenic cells suggests that endothelial cells (ECs) may directly regulate the differentiation of osteoprogenitor cells. To investigate this question, bone marrow stromal cells (BMSCs) were cultured: in the presence of EC-conditioned medium, on EC extracellular matrix, and in EC cocultures with and without cell contact. RNA and protein were isolated from ECs and analyzed by reverse… CONTINUE READING
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