Endothelial cell migration on fibronectin is regulated by syntaxin 6-mediated alpha5beta1 integrin recycling.

@article{Tiwari2011EndothelialCM,
  title={Endothelial cell migration on fibronectin is regulated by syntaxin 6-mediated alpha5beta1 integrin recycling.},
  author={Ajit Tiwari and Jae-Joon Jung and Shivangi M. Inamdar and Charles O. Brown and Apollina Goel and Amit Roy Choudhury},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 42},
  pages={36749-61}
}
The α5β1 integrin heterodimer regulates many processes that contribute to embryonic development and angiogenesis, in both physiological and pathological contexts. As one of the major adhesion complexes on endothelial cells, it plays a vital role in adhesion and migration along the extracellular matrix. We recently showed that angiogenesis is modulated by syntaxin 6, a Golgi- and endosome-localized t-SNARE, and that it does so by regulating the post-Golgi trafficking of VEGFR2. Here we show that… CONTINUE READING