Endothelial cell metabolism in normal and diseased vasculature.

  title={Endothelial cell metabolism in normal and diseased vasculature.},
  author={Guy Eelen and Pauline de Zeeuw and Michael Simons and Peter Carmeliet},
  journal={Circulation research},
  volume={116 7},
Higher organisms rely on a closed cardiovascular circulatory system with blood vessels supplying vital nutrients and oxygen to distant tissues. Not surprisingly, vascular pathologies rank among the most life-threatening diseases. At the crux of most of these vascular pathologies are (dysfunctional) endothelial cells (ECs), the cells lining the blood vessel lumen. ECs display the remarkable capability to switch rapidly from a quiescent state to a highly migratory and proliferative state during… CONTINUE READING
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