Endothelial cell-fatty acid binding protein 4 promotes angiogenesis: role of stem cell factor/c-kit pathway

@article{Elmasri2012EndothelialCA,
  title={Endothelial cell-fatty acid binding protein 4 promotes angiogenesis: role of stem cell factor/c-kit pathway},
  author={Harun Elmasri and Elisa Ghelfi and Chen-wei Yu and Samantha B Traphagen and Manuela Cernadas and Haiming Cao and Guo-Ping Shi and Jorge Plutzky and Mustafa Sahin and G{\^o}khan S. Hotamisligil and Sule Umit Cataltepe},
  journal={Angiogenesis},
  year={2012},
  volume={15},
  pages={457-468}
}
Fatty acid binding protein 4 (FABP4) plays an important role in regulation of glucose and lipid homeostasis as well as inflammation through its actions in adipocytes and macrophages. FABP4 is also expressed in a subset of endothelial cells, but its role in this cell type is not known. We found that FABP4-deficient human umbilical vein endothelial cells (HUVECs) demonstrate a markedly increased susceptibility to apoptosis as well as decreased migration and capillary network formation. Aortic… CONTINUE READING