Endothelial cell dysfunction after ischemic arrest and reperfusion: a possible mechanism of myocardial injury during reflow.

@article{Hashimoto1991EndothelialCD,
  title={Endothelial cell dysfunction after ischemic arrest and reperfusion: a possible mechanism of myocardial injury during reflow.},
  author={Keitaro Hashimoto and Paul Joseph Pearson and Hartzell Vernon Schaff and Raymond Cartier},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={1991},
  volume={102 5},
  pages={688-94}
}
To determine the mechanism(s) responsible for decreased coronary flow after global cardiac ischemia and reperfusion, we studied 40 isolated rabbit hearts before and after 30 minutes of normothermic ischemic arrest and reperfusion. In the control group (n = 10) we evaluated the time course of recovery of coronary flow, vascular reactivity, and myocardial function. In experimental groups A (n = 10) and B (n = 10), metabolic control of autoregulation was assessed by plots of myocardial oxygen… CONTINUE READING
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