Endothelial cell-derived bone mo rphogenetic proteins control proliferation of neural stem/progenitor cells

@article{Mathieu2008EndothelialCB,
  title={Endothelial cell-derived bone mo rphogenetic proteins control proliferation of neural stem/progenitor cells},
  author={C{\'e}line Mathieu and Karine Sii-Felice and Pierre Fouchet and Olivier Etienne and M A Mouthon},
  journal={Molecular and Cellular Neuroscience},
  year={2008},
  volume={38},
  pages={569-577}
}
Neurogenesis persists in the adult brain subventricular zone where neural stem/progenitor cells (NSPCs) lie close to brain endothelial cells (BECs). We show in mouse that BECs produce bone morphogenetic proteins (BMPs). Coculture of embryonic and adult NSPCs with BECs activated the canonical BMP/Smad pathway and reduced their proliferation. We demonstrate that coculture with BECs in the presence of EGF and FGF2 induced a reversible cell cycle exit of NSPCs (LeX+) and an increase in the amount… CONTINUE READING
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