Endothelial cell changes are associated with pulmonary edema and respiratory distress in mice infected with the WA1 human Babesia parasite.

@article{Hemmer1999EndothelialCC,
  title={Endothelial cell changes are associated with pulmonary edema and respiratory distress in mice infected with the WA1 human Babesia parasite.},
  author={Ruth M. Hemmer and Edward J. Wozniak and Linda J. Lowenstine and Charles G. Plopper and Venus W. Wong and Patricia A. Conrad},
  journal={The Journal of parasitology},
  year={1999},
  volume={85 3},
  pages={479-89}
}
A C3H/HeN mouse model was established to study the pathogenesis of the human babesial parasites, WA1 and Babesia microti. To evaluate the course of parasitemia and the associated lesions, mice were inoculated intraperitoneally with either WA1-infected, B. microti-infected, or uninfected hamster red blood cells. WA1-infected mice developed dyspnea and moderate parasitemias, after which death occurred. Babesia microti-infected mice experienced low parasitemias with no apparent morbidity or… CONTINUE READING