Endothelial cell-binding properties of lymphocytes infiltrated into human diabetic pancreas. Implications for pathogenesis of IDDM.

@article{Hnninen1993EndothelialCP,
  title={Endothelial cell-binding properties of lymphocytes infiltrated into human diabetic pancreas. Implications for pathogenesis of IDDM.},
  author={Arno H{\"a}nninen and Marco Salmi and Olli Simell and Sirpa Jalkanen},
  journal={Diabetes},
  year={1993},
  volume={42 11},
  pages={1656-62}
}
In IDDM, mononuclear cells accumulate in the islets of Langerhans and destroy insulin-producing beta-cells. To study the mechanisms that control extravasation of circulating mononuclear cells into the pancreas, we examined the phenotype of vascular endothelium of the pancreas, propagated a T-cell line from pancreatic islets at the onset of the disease and compared endothelial binding of this cell line in vitro to vascular endothelium in different body regions. The adhesion molecules expressed… CONTINUE READING
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